WEKO3
アイテム
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Expression of mRNA for the Angiopoietin-Tie System in Granulosa Cells during Follicular Development in Cows
https://obihiro.repo.nii.ac.jp/records/269
https://obihiro.repo.nii.ac.jp/records/269f5a8f4e4-3b35-4604-8f37-7a6b3291eb23
名前 / ファイル | ライセンス | アクション |
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expression.pdf (157.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||
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公開日 | 2011-06-29 | |||||||||||
タイトル | ||||||||||||
言語 | en | |||||||||||
タイトル | Expression of mRNA for the Angiopoietin-Tie System in Granulosa Cells during Follicular Development in Cows | |||||||||||
言語 | ||||||||||||
言語 | eng | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | Follicular development | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | Angiopoietin-Tie system | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | Granulosa cell | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | Cow | |||||||||||
資源タイプ | ||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
資源タイプ | journal article | |||||||||||
著者 |
Hayashi, Ken-go
× Hayashi, Ken-go× Berisha, Bajram× 松井, 基純
WEKO
132
× Schams, Dieter× Miyamoto, Akio
WEKO
151
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抄録 | ||||||||||||
内容記述タイプ | Abstract | |||||||||||
内容記述 | Recent findings indicate that the changing profile of angiopoietins (ANPT) and their receptor Tie2 are closely associated with development and regression of the vascular network in the cyclic ovary. We previously reported that mRNA expression for the ANPT-Tie system in theca interna changes during bovine follicular development and atresia, and both ANPTs affect steroidogenesis in the preovulatory follicle. The aim of this study was to investigate mRNA expression for ANPT1, ANPT-2 and Tie2 in granulosa cells (GC) during follicular development in the cow. Bovine follicles were classified according to the estradiol-17β (E2) concentration in follicular fluid (FF) as follows: (1) E2<0.5, (2) 0.5<E2<5, (3) 5<E2<20, (4) 20<E2<180 and (5) E2>180 ng/ml FF. Semi-quantitative RT-PCR analysis revealed that the expression of ANPT-1 mRNA was not detected in most of the follicle with E2<5 ng/ml (diameter of 5-10 mm), but clearly detected in all follicles with E2>5 ng/ml (diameter of >10 mm). The mRNA expression for ANPT-2 was drastically decreased in the follicles with E2>5 ng/ml. Tie2 mRNA expression remained unchanged at the different stages of follicular development. The present data show that ANPT-1 becomes predominant in the follicle producing high levels of E2, indicating the possible switch-over from ANPT-2 (antagonist) to ANPT-1 (agonist). Thus, the result suggests that the ANPT-Tie system in bovine GC may stimulate E2 secretion rather than angiogenesis in the late stages of follicular development. | |||||||||||
書誌情報 |
en : Journal of Reproduction and Development 巻 50, 号 4, p. 477-480, 発行日 2004 |
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出版者 | ||||||||||||
出版者 | Japanese Society of Animal Reproduction | |||||||||||
ISSN | ||||||||||||
収録物識別子タイプ | ISSN | |||||||||||
収録物識別子 | 09168818 | |||||||||||
書誌レコードID | ||||||||||||
収録物識別子タイプ | NCID | |||||||||||
収録物識別子 | AA10936678 | |||||||||||
DOI | ||||||||||||
関連タイプ | isIdenticalTo | |||||||||||
識別子タイプ | DOI | |||||||||||
関連識別子 | info:doi/10.1262/jrd.50.477 | |||||||||||
権利 | ||||||||||||
言語 | en | |||||||||||
権利情報 | Japanese Society of Animal Reproduction | |||||||||||
フォーマット | ||||||||||||
内容記述タイプ | Other | |||||||||||
内容記述 | application/pdf | |||||||||||
著者版フラグ | ||||||||||||
出版タイプ | VoR | |||||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |