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Messenger Ribonucleic Acid Expressions of Hepatocyte Growth Factor, Angiopoietins and Their Receptors During Follicular Development in Gilts
https://obihiro.repo.nii.ac.jp/records/234
https://obihiro.repo.nii.ac.jp/records/234a40b261e-373d-4013-92a8-304d8d34a696
名前 / ファイル | ライセンス | アクション |
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shimizu49(3),203-211,2003.pdf (202.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2015-03-31 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Messenger Ribonucleic Acid Expressions of Hepatocyte Growth Factor, Angiopoietins and Their Receptors During Follicular Development in Gilts | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Follicular Development | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Angiogenesis | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | angiopoietins | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | HGF | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Pig | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Shimizu, Takashi
× Shimizu, Takashi× Iijima, Koji× Sasada, Hiroshi× Sato, Eimei |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Angiogenic factors are associated with angiogenesis during follicular development in the mammalian ovary. The aim of the present study was to determine the relationships between the vascular network and mRNA expressions of angiopoietins (Ang)-1, Ang-2 and hepatocyte growth factor (HGF), and their receptors in follicles at different developmental stages during follicular development. Ovaries in gilts were collected 72 h after equine chorionic gonadotropin (eCG, 1250 IU) treatment for histological observation of the capillary network. Granulosa cells and thecal tissues in small (<4 mm), medium (4-5 mm) or large (>5 mm) individual follicles were collected for detection of mRNA expression of HGF, Ang-1 and Ang-2 in granulosa cells, and HGF receptor (HGF-R) and Tie-2 in the theca cells by semi-quantitative RT-PCR. The number of capillaries in the thecal cell layer increased significantly in healthy follicles at all developmental stages in the eCG group compared with those in controls. The expression of Ang-1 mRNA declined in granulosa cells of medium and large follicles and the level of Ang-2 mRNA increased in granulosa cells of small follicles after eCG treatment. The ratio of Ang-2/Ang-1 increased in small, medium and large follicles from ovaries after eCG treatment, but Tie-2 mRNA expression in the theca cells did not change. The level of HGF mRNA increased in granulosa cells of small follicles after eCG treatment but HGF-R in theca cells was not increased by eCG. These data suggested that the angiopoietins might be associated with thecal angiogenesis during follicular development in eCG-treated gilts. | |||||
言語 | en | |||||
書誌情報 |
en : Journal of Reproduction and Development 巻 49, 号 3, p. 203-211, 発行日 2003 |
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出版者 | ||||||
言語 | en | |||||
出版者 | Japanese Society of Animal Reproduction | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 09168818 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10936678 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1262/jrd.49.203 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | Japanese Society of Animal Reproduction | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |