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Cellualr Subsets Involved in Protective Immunity to Babesiarodhaini Infection in BALB/c Mice
名前 / ファイル | ライセンス | アクション |
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Prot.Vol.1-(5).pdf (385.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||
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公開日 | 2006-12-21 | |||||||||||||
タイトル | ||||||||||||||
言語 | en | |||||||||||||
タイトル | Cellualr Subsets Involved in Protective Immunity to Babesiarodhaini Infection in BALB/c Mice | |||||||||||||
言語 | ||||||||||||||
言語 | eng | |||||||||||||
キーワード | ||||||||||||||
主題Scheme | Other | |||||||||||||
主題 | Babesia rodhaini | |||||||||||||
キーワード | ||||||||||||||
言語 | en | |||||||||||||
主題Scheme | Other | |||||||||||||
主題 | cell transfer | |||||||||||||
キーワード | ||||||||||||||
言語 | en | |||||||||||||
主題Scheme | Other | |||||||||||||
主題 | spleen cells | |||||||||||||
キーワード | ||||||||||||||
言語 | en | |||||||||||||
主題Scheme | Other | |||||||||||||
主題 | protective immunity | |||||||||||||
資源タイプ | ||||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
資源タイプ | journal article | |||||||||||||
著者 |
Shimada, Terumasa
× Shimada, Terumasa
WEKO
238
× 五十嵐, 郁男
WEKO
58
× Maki, Yoshiyuki× Claveria, Florencia G.× Saito, Atsushi
WEKO
210
× Suzuki, Naoyoshi |
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抄録 | ||||||||||||||
内容記述タイプ | Abstract | |||||||||||||
内容記述 | Protective immune responses and the functional role of spleen cells in mice infected with Babesia rodhaini were examined with an in vitro proliferation assay systems and by in vivo passive transfer of spleen cells to uninfected mice. Mice that resolved primary babesial infection after chemotherapy (Babesia immune mice) had transient and low parasitemia after challenge infection and high rates (75%) of survival. Babesia hyperimmune mice, by contrast, had no detectable parasitemia after challenge and 100% survival. Proliferative response of spleen cells to Babesia lysate antigen (BLA) were determined for mice from both groups. This proliferative response was inhibited by treatment of spleen cells with anti-T cell serum and monoclonal antibody (MAb) to Lyt l antigen. Spleen cells of hyperimmime mice produced larger amount of IL-2 production than those of immune mice. Transfer of spleen cells from immune mice to nonimmune mice provided protection against babesial infection and recipient mice had high titers of anti-babesial antibody. When these spleen cells were treated with anti-T cell serum or anti-mouse Ig serum, protection against challenge was abolished. By contrast, transfer of hyperimmune spleen cells was capable of protecting recipient mice. Treatment of hyperimmune spleen cells with antiserum to mouse Ig or MAb against Lyt 1 and Lyt 2 antigens did not interfere with their ability to protect recipient mice against infection, even though recipient mice had low levels of antibody production. These results indicate that humoral immune response is important in establishing protection after primary infections while the panicipation of Lyt 1+ cells and Lyt 2+ cells and other aspects of the cell-mediated immune response is important in controlling secondary infections. | |||||||||||||
言語 | en | |||||||||||||
書誌情報 |
en : The journal of protozoology research 巻 1, p. 35-44, 発行日 1991-10 |
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出版者 | ||||||||||||||
言語 | en | |||||||||||||
出版者 | Research Center for Protozoan Molecular Immunology | |||||||||||||
ISSN | ||||||||||||||
収録物識別子タイプ | PISSN | |||||||||||||
収録物識別子 | 09174427 | |||||||||||||
書誌レコードID | ||||||||||||||
収録物識別子タイプ | NCID | |||||||||||||
収録物識別子 | AA10824856 | |||||||||||||
権利 | ||||||||||||||
言語 | en | |||||||||||||
権利情報 | Research Center for Protozoan Molecular Immunology | |||||||||||||
フォーマット | ||||||||||||||
内容記述タイプ | Other | |||||||||||||
内容記述 | application/pdf | |||||||||||||
言語 | en | |||||||||||||
著者版フラグ | ||||||||||||||
出版タイプ | VoR | |||||||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||
日本十進分類法 | ||||||||||||||
主題Scheme | NDC | |||||||||||||
主題 | 649 |