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Determination of serum isometamidium levels in sheep and goats under field conditions using isometamidium-ELISA
https://obihiro.repo.nii.ac.jp/records/1540
https://obihiro.repo.nii.ac.jp/records/1540e452c689-a992-4dee-9c78-5e1b1333e1f5
名前 / ファイル | ライセンス | アクション |
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Prot.Vol.10-4-4.pdf (206.5 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2006-12-19 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Determination of serum isometamidium levels in sheep and goats under field conditions using isometamidium-ELISA | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Isometamidium chloride | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | ELISA | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Sheep | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Goats | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Trypanosomosis | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Wesongah, J. O.
× Wesongah, J. O.× Murilla, G. A.× Kibugu, J. K.× Jones, T. W. |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Twenty eight sheep and 28 goats were treated with isometamidium chloride (Samorin®, hone Merieux, Lyon, France) at a dose of 1 mg/kg body weight (bw) by intramuscular injection. All the animals were grazed in a tsetse-infested area. They were monitored for anaemia, body weight, anti-trypanosome antibodies and serum isometamidium concentration using the isometamidium enzyme-linked immunosorbent assay (ELISA) for more than 80 days after treatment. Serum isometamidium levels were higher in goats than in sheep throughout the experimental period. Isometamidium was still detectable in sheep and goats for up to 77 and 98 days, respectively, alter treatment (detection limit=0.1 ng/ml). The isometamidium elimination half-lives in sheep and goats were approximately 13.8 and 17.4 days, respectively. No trypanosomes were detected in either the isometamidium-treated or untreated control animals. The present study demonstrated that the isometamidium-ELISA, originally developed for use in cattle, may be equally useful in monitoring the drug in sheep and goats. The elimination half-lives and serum isometamidium levels were markedly higher in goats than in sheep. This could have important implications for chemoprophylaxis in small ruminants under field conditions. | |||||
言語 | en | |||||
書誌情報 |
en : The journal of protozoology research 巻 10, 号 4, p. 191-201, 発行日 2000-10 |
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出版者 | ||||||
言語 | en | |||||
出版者 | National Research Center for Protozoan Diseases | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 09174427 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10824856 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | National Research Center for Protozoan Diseases | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
日本十進分類法 | ||||||
主題Scheme | NDC | |||||
主題 | 649 |