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Changes of splenic interleukin-12p70 concentration in mice infected with Babesia microti and Babesia rodhaini
https://obihiro.repo.nii.ac.jp/records/1497
https://obihiro.repo.nii.ac.jp/records/1497dc076163-e338-4e42-917f-a116a3e6e45b
名前 / ファイル | ライセンス | アクション |
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Prot.Vol15-(6).pdf (140.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||||
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公開日 | 2006-12-20 | |||||||
タイトル | ||||||||
言語 | en | |||||||
タイトル | Changes of splenic interleukin-12p70 concentration in mice infected with Babesia microti and Babesia rodhaini | |||||||
言語 | ||||||||
言語 | eng | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | Babesia microti | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | Babesia rodhaini | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | cell-mediated immunity | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | early phase of infection | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | IL-12p70 | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | Th1 cell differentiation | |||||||
資源タイプ | ||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
資源タイプ | journal article | |||||||
著者 |
Ohmori, Takashi
× Ohmori, Takashi× Tamahara, Satoshi× Thi, Pham Ngoc× Tomihari, Mizuki× Shimada, Terumasa
WEKO
238
× Matsuki, Naoaki× Ono, Kenichiro |
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抄録 | ||||||||
内容記述タイプ | Abstract | |||||||
内容記述 | Interleukin-12 (IL-12) is one of the most important factors for the host’s protective immune response against protozoan infection. To evaluate the effect of bioactive form of IL-12(IL-12p70), expression of IFN-AmRNA and IL-4 mRNA in splenic CD4 positive T cells, anti-parasite delayed type hypersensitivity (DTH), and serum and splenic IL-12p70 concentration were examined in Babesia microti and B. rodhaini infected mice. The expression of IFN-AmRNA as a marker of Th1 cell differentiation was detected in splenic CD4 positive T cells in B. microti infected mice. Activation of DTH response as a marker of cell-mediated immune response was also observed from 2 days after the infection with B. microti, while no response was detected in B. rodhaini infected mice. Serum IL-12p70 was not detected in both B. microti and B. rodhaini infected mice, however, splenic IL-12p70 concentration increased significantly in B. microti infected mice with peaks at 30 hrs and 4 days after the infection. From these results, splenic IL-12p70 increased at 30 hrs after the B. microti infection was considered to closely relate with Th1 cell differentiation followed by cell-mediated immune response in mice. | |||||||
言語 | en | |||||||
書誌情報 |
en : The journal of protozoology research 巻 15, 号 3-4, p. 41-47, 発行日 2005-10 |
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出版者 | ||||||||
言語 | en | |||||||
出版者 | National Research Center for Protozoan Diseases | |||||||
ISSN | ||||||||
収録物識別子タイプ | PISSN | |||||||
収録物識別子 | 09174427 | |||||||
書誌レコードID | ||||||||
収録物識別子タイプ | NCID | |||||||
収録物識別子 | AA10824856 | |||||||
権利 | ||||||||
言語 | en | |||||||
権利情報 | National Research Center for Protozoan Diseases | |||||||
フォーマット | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | application/pdf | |||||||
著者版フラグ | ||||||||
出版タイプ | VoR | |||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
日本十進分類法 | ||||||||
主題Scheme | NDC | |||||||
主題 | 649 |