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In vitro inhibitory effect of fosmidomycin on the asexual growth of Babesia bovis and Babesia bigemina
https://obihiro.repo.nii.ac.jp/records/1470
https://obihiro.repo.nii.ac.jp/records/1470272f2790-181e-46b5-88e4-006304d9264c
名前 / ファイル | ライセンス | アクション |
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S090202-4.pdf (250.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||
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公開日 | 2009-02-02 | |||||||||||||
タイトル | ||||||||||||||
言語 | en | |||||||||||||
タイトル | In vitro inhibitory effect of fosmidomycin on the asexual growth of Babesia bovis and Babesia bigemina | |||||||||||||
言語 | ||||||||||||||
言語 | eng | |||||||||||||
キーワード | ||||||||||||||
言語 | en | |||||||||||||
主題Scheme | Other | |||||||||||||
主題 | Fosmidomycin | |||||||||||||
キーワード | ||||||||||||||
言語 | en | |||||||||||||
主題Scheme | Other | |||||||||||||
主題 | Babesia bovis | |||||||||||||
キーワード | ||||||||||||||
言語 | en | |||||||||||||
主題Scheme | Other | |||||||||||||
主題 | Babesia bigemina | |||||||||||||
キーワード | ||||||||||||||
言語 | en | |||||||||||||
主題Scheme | Other | |||||||||||||
主題 | asexual growth | |||||||||||||
キーワード | ||||||||||||||
言語 | en | |||||||||||||
主題Scheme | Other | |||||||||||||
主題 | in vitro culture | |||||||||||||
資源タイプ | ||||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
資源タイプ | journal article | |||||||||||||
著者 |
Sivakumar, Thillaiampalam
× Sivakumar, Thillaiampalam× Aboulaila, M. R. A.× Khukhuu, A× Iseki, H× Alhassan, A× 横山, 直明
WEKO
312
× 五十嵐, 郁男
WEKO
58
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抄録 | ||||||||||||||
内容記述タイプ | Abstract | |||||||||||||
内容記述 | The in vitro inhibitory effect of fosmidomycin was evaluated against the asexual growth of bovine Babesia parasites (Babesia bovis and Babesia bigemina). In the cultures with these parasites, severe reduction of parasite growth was observed by the addition of 1.25 μg/ml of the final drug concentration. Under these conditions, B. bigemina was completely cleared until the third day of cultivation. On the other hand, B. bovis was completely eliminated on the fourth day when the concentration was 6.25 μg/ml in the culture. These parasites failed to grow again when a drug-free medium was substituted for the subsequent cultivation. The IC50 values of fosmidomycin against B. bovis were determined as 0.88 and 0.63 μg/ml in the in vitro cultures with serum-containing M199 and serum-free GIT media, respectively, while it was 0.55 μg/ml against B. bigemina in a serum-containing M199 medium. Severe morphological changes, such as pycnotic and degenerative changes, were preferably observed in the treated parasites. These results suggest that fosmidomycin can be a potent chemotherapeutic agent against bovine babesiosis. | |||||||||||||
言語 | en | |||||||||||||
書誌情報 |
en : The journal of protozoology research 巻 18, 号 2, p. 71-78, 発行日 2008-12 |
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出版者 | ||||||||||||||
言語 | en | |||||||||||||
出版者 | National Research Center for Protozoan Diseases | |||||||||||||
ISSN | ||||||||||||||
収録物識別子タイプ | PISSN | |||||||||||||
収録物識別子 | 09174427 | |||||||||||||
書誌レコードID | ||||||||||||||
収録物識別子タイプ | NCID | |||||||||||||
収録物識別子 | AA10824856 | |||||||||||||
権利 | ||||||||||||||
言語 | en | |||||||||||||
権利情報 | National Research Center for Protozoan Diseases | |||||||||||||
フォーマット | ||||||||||||||
内容記述タイプ | Other | |||||||||||||
内容記述 | application/pdf | |||||||||||||
著者版フラグ | ||||||||||||||
出版タイプ | VoR | |||||||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||
日本十進分類法 | ||||||||||||||
主題Scheme | NDC | |||||||||||||
主題 | 649 |