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Identification of compounds that suppress Toxoplasma gondii tachyzoites and bradyzoites
https://obihiro.repo.nii.ac.jp/records/1284
https://obihiro.repo.nii.ac.jp/records/128495838780-a4fb-48d9-b9bf-4c53603b8f12
名前 / ファイル | ライセンス | アクション |
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journal.pone.0178203.pdf (2.5 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-08-28 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Identification of compounds that suppress Toxoplasma gondii tachyzoites and bradyzoites | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Murata, Yuho
× Murata, Yuho× Sugi, Tatsuki× Weiss, Louis M.× 加藤, 健太郎 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Drug treatment for toxoplasmosis is problematic, because current drugs cannot eradicate latent infection with Toxoplasma gondii and can cause bone marrow toxicity. Because latent infection remains after treatment, relapse of infection is a problem in both infections in immunocompromised patients and in congenitally infected patients. To identify lead compounds for novel drugs against Toxoplasma gondii, we screened a chemical compound library for anti-Toxoplasma activity, host cell cytotoxicity, and effect on bradyzoites. Of 878 compounds screened, 83 demonstrated > 90% parasite growth inhibition. After excluding compounds that affected host cell viability, we further characterized two compounds, tanshinone IIA and hydroxyzine, which had IC50 values for parasite growth of 2.5 mu M and 1.0 mu M, respectively, and had no effect on host cell viability at 25 mu M. Both tanshinone IIA and hydroxyzine inhibited parasite replication after invasion and both reduced the number of in vitro-induced bradyzoites, whereas, pyrimethamine, the current therapy, had no effect on bradyzoites. Both tanshinone IIA and hydroxyzine are potent lead compounds for further medicinal chemistry. The method presented for evaluating compounds for bradyzoite efficacy represents a new approach to the development of anti-Toxoplasma drugs to eliminate latency and treat acute infection. | |||||
言語 | en | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Supporting information is available on the original article website. | |||||
書誌情報 |
en : Plos One 巻 12, 号 6, p. e0178203, 発行日 2017-06-13 |
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出版者 | ||||||
言語 | en | |||||
出版者 | PLOS | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 19326203 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1371/journal.pone.0178203 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | This is an open access article licensed under the terms of the Creative Commons Attribution (by) License. <http://creativecommons.org/lisenses/by/4.0/> | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |