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Immunization with Toxoplasma gondii peroxiredoxin 1 induces protective immunity against toxoplasmosis in mice
https://obihiro.repo.nii.ac.jp/records/1277
https://obihiro.repo.nii.ac.jp/records/12777c5887b6-08af-485e-b54c-a4af022fcfe4
名前 / ファイル | ライセンス | アクション |
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file.pdf (3.9 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||
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公開日 | 2017-08-30 | |||||||||||
タイトル | ||||||||||||
言語 | en | |||||||||||
タイトル | Immunization with Toxoplasma gondii peroxiredoxin 1 induces protective immunity against toxoplasmosis in mice | |||||||||||
言語 | ||||||||||||
言語 | eng | |||||||||||
資源タイプ | ||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
資源タイプ | journal article | |||||||||||
著者 |
Fereig, Ragab M.
× Fereig, Ragab M.× Kuroda, Yasuhiro× Terkawi, Mohamad Alaa
WEKO
359
× Mahmoud, Motamed Elsayed× 西川, 義文
WEKO
176
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抄録 | ||||||||||||
内容記述タイプ | Abstract | |||||||||||
内容記述 | To develop a vaccine against Toxoplasma gondii, a vaccine antigen with immune-stimulating activity is required. In the present study, we investigated the immunogenicity and prophylactic potential of T. gondii peroxiredoxin 1 (TgPrx1). The TgPrx1 was detected in the ascitic fluid of mice 6 days postinfection, while specific antibody levels were low in the sera of chronically infected mice. Treatment of murine peritoneal macrophages with recombinant TgPrx1 triggered IL-12p40 and IL-6 production, but not IL-10 production. In response to TgPrx1, activation of NF-kappa B and IL-6 production were confirmed in mouse macrophage cell line (RAW 264.7). These results suggest the immune-stimulating potentials of TgPrx1. Immunization of mice with recombinant TgPrx1 stimulated specific antibody production (IgG1 and IgG2c). Moreover, spleen cell proliferation and interferon-gamma production significantly increased in the TgPrx1-sensitized cells from mice immunized with the same antigen. Immunization with TgPrx1 also increased mouse survival and decreased cerebral parasite burden against lethal T. gondii infection. Thus, our results suggest that TgPrx1 efficiently induces humoral and cellular immune responses and is useful as a new vaccine antigen against toxoplasmosis. | |||||||||||
言語 | en | |||||||||||
書誌情報 |
en : Plos One 巻 12, 号 4, p. e0176324, 発行日 2017-04-27 |
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出版者 | ||||||||||||
言語 | en | |||||||||||
出版者 | PLOS | |||||||||||
ISSN | ||||||||||||
収録物識別子タイプ | PISSN | |||||||||||
収録物識別子 | 19326203 | |||||||||||
DOI | ||||||||||||
関連タイプ | isIdenticalTo | |||||||||||
識別子タイプ | DOI | |||||||||||
関連識別子 | info:doi/10.1371/journal.pone.0176324 | |||||||||||
権利 | ||||||||||||
言語 | en | |||||||||||
権利情報 | This is an open access article licensed under the terms of the Creative Commons Attribution (by) License. <http://creativecommons.org/lisenses/by/4.0/> | |||||||||||
フォーマット | ||||||||||||
内容記述タイプ | Other | |||||||||||
内容記述 | application/pdf | |||||||||||
著者版フラグ | ||||||||||||
出版タイプ | VoR | |||||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
日本十進分類法 | ||||||||||||
主題Scheme | NDC | |||||||||||
主題 | 491 |