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Modulation of host HIF-1α activity and the tryptophan pathway contributes to the anti-Toxoplasma gondii potential of nanoparticles
https://obihiro.repo.nii.ac.jp/records/1246
https://obihiro.repo.nii.ac.jp/records/1246a53285a9-d10d-4f20-94c8-26028c9330a5
名前 / ファイル | ライセンス | アクション |
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1-s2.0-S2405580817301267-main.pdf (3.2 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-16 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Modulation of host HIF-1α activity and the tryptophan pathway contributes to the anti-Toxoplasma gondii potential of nanoparticles | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Hypoxia | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Indoleamine 2,3-dioxygenase | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Mechanism of action | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Nanomedicine | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Toxoplasmosis | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Adeyemi, Oluyomi Stephen
× Adeyemi, Oluyomi Stephen× Murata, Yuho× Sugi, Tatsuki× Han, Yongmei× 加藤, 健太郎 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background Toxoplasmosis constitutes a large global burden that is further exacerbated by the shortcomings of available therapeutic options, thus underscoring the urgent need for better anti-Toxoplasma gondii therapy or strategies. Recently, we showed that the anti-parasitic action of inorganic nanoparticles (NPs) could, in part, be due to changes in redox status as well as in the parasite mitochondrial membrane potential. Methods In the present study, we explored the in vitro mode of action of the anti-T. gondii effect of NPs by evaluating the contributions of host cellular processes, including the tryptophan pathway and hypoxia-inducing factor activity. NPs, at concentrations ranging from 0.01 to 200 μg/ml were screened for anti-parasitic activity. Sulfadiazine and/or pyrimethamine served as positive controls. Results We found that interplay among multiple host cellular processes, including HIF-1α activity, indoleamine 2,3-dioxygenase activity, and to a larger extent the tryptophan pathway, contribute to the anti-parasitic action of NPs. Conclusion To our knowledge, this is the first study to demonstrate an effect of NPs on the tryptophan and/or kynurenine pathway. General significance Our findings deepen our understanding of the mechanism of action of NPs and suggest that modulation of the host nutrient pool may represent a viable approach to the development of new and effective anti-parasitic agents. |
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言語 | en | |||||
書誌情報 |
en : Biochemistry and Biophysics Reports 巻 11, p. 84-92, 発行日 2017 |
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出版者 | ||||||
言語 | en | |||||
出版者 | Elsevier | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 24055808 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/). | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
日本十進分類法 | ||||||
主題Scheme | NDC | |||||
主題 | 464 |