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Effects of Extracts from Thai Piperaceae Plants against Infection with Toxoplasma gondii
https://obihiro.repo.nii.ac.jp/records/1206
https://obihiro.repo.nii.ac.jp/records/12065dbaf4f2-c29e-4df8-884d-18e3a2288cb0
名前 / ファイル | ライセンス | アクション |
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file.pdf (1.3 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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公開日 | 2017-08-30 | |||||||||
タイトル | ||||||||||
言語 | en | |||||||||
タイトル | Effects of Extracts from Thai Piperaceae Plants against Infection with Toxoplasma gondii | |||||||||
言語 | ||||||||||
言語 | eng | |||||||||
資源タイプ | ||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
資源タイプ | journal article | |||||||||
著者 |
Leesombun, Arpron
× Leesombun, Arpron× Boonmasawai, Sookruetai× Shimoda, Naomi× 西川, 義文
WEKO
176
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抄録 | ||||||||||
内容記述タイプ | Abstract | |||||||||
内容記述 | Herbal medicines and natural herb extracts are widely used as alternative treatments for various parasitic diseases, and such extracts may also have potential to decrease the side effects of the standard regimen drugs used to treat toxoplasmosis (sulfadiazine-pyrimethamine combination). We evaluated how effective the Thai piperaceae plants Piper betle, P. nigrum and P. sarmentosum are against Toxoplasma gondii infection in vitro and in vivo. Individually, we extracted the piperaceae plants with ethanol, passed them through a rotary evaporator and then lyophilized them to obtain crude extracts for each one. The in vitro study indicated that the P. betle extract was the most effective extract at inhibiting parasite growth in HFF cells (IC50 on RH-GFP: 23.2 mu g/mL, IC50 on PLK-GFP: 21.4 mu g/mL). Further-more, treatment of experimental mice with the P. betle extract for 7 days after infection with 1,000 tachyzoites of the T. gondii PLK strain increased their survival (survival rates: 100% in 400 mg/kg-treated, 83.3% in 100 mg/kg-treated, 33.3% in 25 mg/kg-treated, 33.3% in untreated mice). Furthermore, treatment with 400 mg/kg of the P. betle extract resulted in 100% mouse survival following infection with 100,000 tachyzoites. The present study shows that P. betle extract has the potential to act as a medical plant for the treatment of toxoplasmosis. | |||||||||
言語 | en | |||||||||
書誌情報 |
en : Plos One 巻 11, 号 5, p. e0156116, 発行日 2016-05-23 |
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出版者 | ||||||||||
言語 | en | |||||||||
出版者 | PLOS | |||||||||
ISSN | ||||||||||
収録物識別子タイプ | PISSN | |||||||||
収録物識別子 | 19326203 | |||||||||
DOI | ||||||||||
関連タイプ | isIdenticalTo | |||||||||
識別子タイプ | DOI | |||||||||
関連識別子 | info:doi/10.1371/journal.pone.0156116 | |||||||||
権利 | ||||||||||
言語 | en | |||||||||
権利情報 | This is an open access article licensed under the terms of the Creative Commons Attribution (by) License. <http://creativecommons.org/lisenses/by/4.0/> | |||||||||
フォーマット | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | application/pdf | |||||||||
著者版フラグ | ||||||||||
出版タイプ | VoR | |||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
日本十進分類法 | ||||||||||
主題Scheme | NDC | |||||||||
主題 | 471 |