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Dextran sulfate inhibits acute Toxoplama gondii infection in pigs
https://obihiro.repo.nii.ac.jp/records/1198
https://obihiro.repo.nii.ac.jp/records/1198792c2d3d-d862-4736-ac12-cbf327d75e43
名前 / ファイル | ライセンス | アクション |
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s13071-016-1421-9.pdf (2.7 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||||
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公開日 | 2017-08-28 | |||||||
タイトル | ||||||||
言語 | en | |||||||
タイトル | Dextran sulfate inhibits acute Toxoplama gondii infection in pigs | |||||||
言語 | ||||||||
言語 | eng | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | Dextran sulfate | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | Intermediate host | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | Pig | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | Public health | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | Toxoplasma gondii | |||||||
資源タイプ | ||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
資源タイプ | journal article | |||||||
著者 |
加藤, 健太郎
× 加藤, 健太郎× Murata, Yuho× 堀内, 雅之× Inomata, Atsuko× Terkawi, Mohamad Alaa
WEKO
359
× Ishiwa, Akiko× Ogawa, Yohsuke× 福本, 晋也× Matsuhisa, Fumikazu× Koyama, Kenji |
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抄録 | ||||||||
内容記述タイプ | Abstract | |||||||
内容記述 | Background: Toxoplasma gondii is a highly prevalent protozoan that can infect all warm-blooded animals, including humans. Its definitive hosts are Felidae and its intermediate hosts include various other mammals and birds, including pigs. It is found in the meat of livestock which is a major source of human infection. Hence the control of toxoplasmosis in pigs is important for public health. We previously showed that dextran sulfate (DS), especially DS10 (dextran sulfate MW 10 kDa), is effective against T. gondii infection both in vitro and in mice. In this study, we asked whether DS affects T. gondii infection of pigs, one of the main animal sources of toxoplasmosis transmission to humans. Methods: Fourteen-day-old male pigs (n = 10) were infected with T. gondii and then immediately treated with different doses of DS10; clinical, pathological, and immunological analyses were performed 5 days post-infection. Results: DS10 had an inhibitory effect on toxoplasmosis in pigs. Intravenous injection of DS10 prevented the symptoms of toxoplasmosis and reduced the parasite burden and inflammation induced by T. gondii infection. High-dose DS10 (500 mu g per head) caused reversible hepatocellular degeneration of the liver; middle-dose DS10 (50 mu g per head) was effective against toxoplasmosis in pigs without causing this side effect. Conclusions: Our data suggest that middle-dose DS10 led to minimal clinical symptoms of T. gondii infection and caused little hepatocellular degeneration in our pig model, thereby demonstrating its potential as a new treatment for toxoplasmosis. These data should be very beneficial to those interested in the control of toxoplasmosis in pigs. |
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言語 | en | |||||||
書誌情報 |
en : Parasites & Vectors 巻 9, p. 134, 発行日 2016-03-09 |
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出版者 | ||||||||
言語 | en | |||||||
出版者 | BioMed Central | |||||||
ISSN | ||||||||
収録物識別子タイプ | PISSN | |||||||
収録物識別子 | 17563305 | |||||||
DOI | ||||||||
関連タイプ | isIdenticalTo | |||||||
識別子タイプ | DOI | |||||||
関連識別子 | info:doi/10.1186/s13071-016-1421-9 | |||||||
権利 | ||||||||
言語 | en | |||||||
権利情報 | This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/). | |||||||
フォーマット | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | application/pdf | |||||||
著者版フラグ | ||||||||
出版タイプ | VoR | |||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
日本十進分類法 | ||||||||
主題Scheme | NDC | |||||||
主題 | 498 |