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MEIS3 is repressed in A549 lung epithelial cells by deoxynivalenol and the repression contributes to the deleterious effect
https://obihiro.repo.nii.ac.jp/records/1146
https://obihiro.repo.nii.ac.jp/records/114646c06408-0069-4515-95ec-82b5c7afe257
名前 / ファイル | ライセンス | アクション |
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toyotome41(1),25-31,2016.pdf (955.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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公開日 | 2016-06-23 | |||||||||
タイトル | ||||||||||
言語 | en | |||||||||
タイトル | MEIS3 is repressed in A549 lung epithelial cells by deoxynivalenol and the repression contributes to the deleterious effect | |||||||||
言語 | ||||||||||
言語 | eng | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | Fusarium toxin | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | Mycotoxin | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | Deoxynivalenol | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | Trichothecene | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | Lung epithelial cell | |||||||||
資源タイプ | ||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
資源タイプ | journal article | |||||||||
著者 |
豊留, 孝仁
× 豊留, 孝仁
WEKO
284
× Takahashi, Hiroki× Kamei, Katsuhiko |
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抄録 | ||||||||||
内容記述タイプ | Abstract | |||||||||
内容記述 | Deoxynivalenol (DON) is an important Fusarium toxin of concern for food safety. The inhalation of powder contaminated with DON is possible and may cause lung toxicity. In this study, we analyzed the gene expression profile of A549 cells treated for 24 hr with 0.2 µg/mL DON by microarray analysis. In total, 16 genes and 5 noncoding RNAs were significantly affected by DON treatment. The repression of B3GALT4, MEIS3, AK7, SEMA3A, KCNMB4, and SCARA5 was confirmed by quantitative PCR. We investigated the DON toxicity on A549 cells that exogenously expressed these 6 genes. The result indicated that A549 cells that transiently expressed MEIS3 were tolerant to the deleterious effects of DON. Our data show that DON affected the expression of genes with various functions, and suggest that the repression of MEIS3 plays roles in the deleterious effect of DON in A549 lung epithelial cells. | |||||||||
言語 | en | |||||||||
書誌情報 |
en : Journal of Toxicological Sciences 巻 41, 号 1, p. 25-31, 発行日 2016 |
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出版者 | ||||||||||
言語 | en | |||||||||
出版者 | Japanese Society of Toxicology | |||||||||
ISSN | ||||||||||
収録物識別子タイプ | PISSN | |||||||||
収録物識別子 | 03881350 | |||||||||
書誌レコードID | ||||||||||
収録物識別子タイプ | NCID | |||||||||
収録物識別子 | AN00002808 | |||||||||
DOI | ||||||||||
関連タイプ | isIdenticalTo | |||||||||
識別子タイプ | DOI | |||||||||
関連識別子 | info:doi/10.2131/jts.41.25 | |||||||||
権利 | ||||||||||
権利情報 | Japanese Society of Toxicology | |||||||||
フォーマット | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | application/pdf | |||||||||
著者版フラグ | ||||||||||
出版タイプ | VoR | |||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |