http://swrc.ontoware.org/ontology#Article
Measurements of body surface area and volume in laboratory rabbits (New Zealand white rabbits) using a computed tomography scanner
en
Body surface area
Computed tomography
CT image
CT scanner
Rabbit
Itoh Tadashi
Kawabe Mifumi
Nagase Takahiko
Koike Tsuneo
Miyoshi Masafumi
Miyahara Kazuro
The body surface area (BSA) of an organism is one of the important parameters for evaluating physiological functions. In drug development, normalization by BSA is an appropriate method for extrapolating doses between species. The BSA of animals has generally been estimated by multiplying the k value by 2/3 of the power of the body weight (BW) (Meeh’s formula). In mathematics, if it is assumed that the density and body shape of the animals are essentially constant, the BSA is proportional to BW2/3. In this study, we measured the BSA and volume (V) of 72 laboratory rabbits (48 males and 24 females of New Zealand White rabbits [NZW]), using a computed tomography scanner. After BSA and V determination, the k value, density, and sphericity were calculated. We analyzed variations in the k value, density, and body shape of laboratory rabbits. The mean k value of the 72 NZW was 11.0. We advocate using Meeh’s formula, as follows, for estimating BSA of laboratory rabbits (NZW): 100 × BSA [m2] = 11.0 × BW [kg]2/3. © 2018 Japanese Association for Laboratory Animal Science.
Experimental Animals
67
4
527-534
2018
Japanese Association for Laboratory Animal Science
13411357
AA11032321
info:doi/10.1538/expanim.18-0028
application/pdf
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