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Inhibitory Effects of Pepstatin A and Mefloquine on the Growth of Babesia Parasites
名前 / ファイル | ライセンス | アクション |
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681.pdf (1.4 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||
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公開日 | 2013-12-20 | |||||||||||||||
タイトル | ||||||||||||||||
言語 | en | |||||||||||||||
タイトル | Inhibitory Effects of Pepstatin A and Mefloquine on the Growth of Babesia Parasites | |||||||||||||||
言語 | ||||||||||||||||
言語 | eng | |||||||||||||||
資源タイプ | ||||||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||
資源タイプ | journal article | |||||||||||||||
著者 |
Munkhjargal, Tserendorj
× Munkhjargal, Tserendorj× Aboulaila, Mahmoud× Terkawi, Mohamad Alaa
WEKO
359
× Sivakumar, Thillaiampalam× Ichikawa, Madoka× Davaasuren, Batdorj× Nyamjargal, Tserendorj× 横山, 直明
WEKO
312
× 五十嵐, 郁男
WEKO
58
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抄録 | ||||||||||||||||
内容記述タイプ | Abstract | |||||||||||||||
内容記述 | We evaluated the inhibitory effects of pepstatin A and mefloquine on the in vitro and in vivo growths of Babesia parasites. The in vitro growth of Babesia bovis, B. bigemina, B. caballi, and B. equi was significantly inhibited (P < 0.05) by micromolar concentrations of pepstatin A (50% inhibitory concentrations = 38.5, 36.5, 17.6, and 18.1 μM, respectively) and mefloquine (50% inhibitory concentrations = 59.7, 56.7, 20.7, and 4 μM, respectively). Furthermore, both reagents either alone at a concentration of 5 mg/kg or in combinations (2.5/2.5 and 5/5 mg/kg) for 10 days significantly inhibited the in vivo growth of B. microti in mice. Mefloquine treatment was highly effective and the combination treatments were less effective than other treatments. Therefore, mefloquine may antagonize the actions of pepstatin A against babesiosis and aspartic proteases may play an important role in the asexual growth cycle of Babesia parasites. | |||||||||||||||
言語 | en | |||||||||||||||
書誌情報 |
en : American Journal of Tropical Medicine and Hygiene 巻 87, 号 4, p. 681-688, 発行日 2012 |
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言語 | en | |||||||||||||||
出版者 | American Society of Tropical Medicine and Hygiene | |||||||||||||||
ISSN | ||||||||||||||||
収録物識別子タイプ | PISSN | |||||||||||||||
収録物識別子 | 00029637 | |||||||||||||||
書誌レコードID | ||||||||||||||||
収録物識別子タイプ | NCID | |||||||||||||||
収録物識別子 | AA00521439 | |||||||||||||||
権利 | ||||||||||||||||
言語 | en | |||||||||||||||
権利情報 | American Society of Tropical Medicine and Hygiene | |||||||||||||||
関連サイト | ||||||||||||||||
識別子タイプ | URI | |||||||||||||||
関連識別子 | http://www.ajtmh.org/content/87/4/681.abstract | |||||||||||||||
関連名称 | http://www.ajtmh.org/content/87/4/681.abstract | |||||||||||||||
フォーマット | ||||||||||||||||
内容記述タイプ | Other | |||||||||||||||
内容記述 | application/pdf | |||||||||||||||
著者版フラグ | ||||||||||||||||
出版タイプ | VoR | |||||||||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |