WEKO3
アイテム
{"_buckets": {"deposit": "e9cbcf7d-a305-483a-bd75-e00338c213a7"}, "_deposit": {"created_by": 12, "id": "4778", "owners": [12], "pid": {"revision_id": 0, "type": "depid", "value": "4778"}, "status": "published"}, "_oai": {"id": "oai:obihiro.repo.nii.ac.jp:00004778", "sets": ["5"]}, "author_link": ["6667", "6671", "6668", "6669", "336", "1980", "6670", "176"], "item_2_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2021-12", "bibliographicIssueDateType": "Issued"}, "bibliographicPageStart": "102424", "bibliographicVolumeNumber": "85", "bibliographic_titles": [{"bibliographic_title": "Parasitology International", "bibliographic_titleLang": "en"}]}]}, "item_2_description_19": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_2_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "179 compounds in a Mongolian compound library were investigated for their inhibitory effect on the in vitro growth of Plasmodium falciparum and Toxoplasma gondii. Among these compounds, brachangobinan A at a half-maximal inhibition concentration (IC50) of 2.62 μM and a selectivity index (SI) of 27.91; 2-(2′-hydroxy-5′-O-methylphenyl)-5-(2″,5″-dihydroxyphenyl)oxazole (IC50 3.58 μM and SI 24.66); chrysosplenetin (IC50 3.78 μM and SI 15.26); 4,11-di-O-galloylbergenin (IC50 3.87 μM and SI 13.38); and 2-(2′,5′-dihydroxyphenyl)-5-(2″-hydroxyphenyl)oxazole (IC50 6.94 μM and SI 11.48) were identified as potential inhibitors of P. falciparum multiplication. Additionally, tricin (IC50 12.94 μM and SI \u003e 23.40) was identified as a potential inhibitor of T. gondii multiplication. Our findings represent a good starting point for developing novel antimalarial and anti-Toxoplasma therapeutics from Mongolian compounds.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_2_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Elsevier"}]}, "item_2_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "info:doi/10.1016/j.parint.2021.102424", "subitem_relation_type_select": "DOI"}}]}, "item_2_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA11112001", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "13835769", "subitem_source_identifier_type": "ISSN"}]}, "item_2_subject_21": {"attribute_name": "日本十進分類法", "attribute_value_mlt": [{"subitem_subject": "649", "subitem_subject_scheme": "NDC"}]}, "item_2_text_25": {"attribute_name": "文献提供者", "attribute_value_mlt": [{"subitem_text_value": "西川義文 nisikawa@obihiro.ac.jp"}]}, "item_2_textarea_24": {"attribute_name": "作業記録", "attribute_value_mlt": [{"subitem_textarea_value": "repo202203-13; 2022/5/13西川先生に依頼(著者版); 2022/5/16 OK; エンバーゴ 2022/8/4;"}]}, "item_2_version_type_20": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Banzragchgarav, Orkhon", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6667", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ariefta, Nanang R.", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6668", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Murata, Toshihiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6669", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Myagmarsuren, Punsantsogvoo", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6670", "nameIdentifierScheme": "WEKO"}]}, {"creatorAffiliations": [{"affiliationNameIdentifiers": [{"affiliationNameIdentifier": "", "affiliationNameIdentifierScheme": "ISNI", "affiliationNameIdentifierURI": "http://www.isni.org/isni/"}], "affiliationNames": [{"affiliationName": "", "affiliationNameLang": "ja"}]}], "creatorNames": [{"creatorName": "Battsetseg, Badgar", "creatorNameLang": "en"}], "familyNames": [{"familyName": "Battsetseg", "familyNameLang": "en"}], "givenNames": [{"givenName": "Badgar", "givenNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "336", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "9000005514117", "nameIdentifierScheme": "CiNii ID", "nameIdentifierURI": "http://ci.nii.ac.jp/nrid/9000005514117"}]}, {"creatorNames": [{"creatorName": "Battur, Banzragch", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1980", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Batkhuu, Javzan", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6671", "nameIdentifierScheme": "WEKO"}]}, {"creatorAffiliations": [{"affiliationNameIdentifiers": [{"affiliationNameIdentifier": "", "affiliationNameIdentifierScheme": "ISNI", "affiliationNameIdentifierURI": "http://www.isni.org/isni/"}], "affiliationNames": [{"affiliationName": "", "affiliationNameLang": "ja"}]}], "creatorNames": [{"creatorName": "Nishikawa, Yoshifumi", "creatorNameLang": "en"}, {"creatorName": "西川, 義文", "creatorNameLang": "ja"}], "familyNames": [{"familyName": "Nishikawa", "familyNameLang": "en"}, {"familyName": "西川", "familyNameLang": "ja"}], "givenNames": [{"givenName": "Yoshifumi", "givenNameLang": "en"}, {"givenName": "義文", "givenNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "176", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "9000000186605", "nameIdentifierScheme": "CiNii ID", "nameIdentifierURI": "http://ci.nii.ac.jp/nrid/9000000186605"}, {"nameIdentifier": "90431395", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=90431395"}, {"nameIdentifier": "read0136808", "nameIdentifierScheme": "researchmap", "nameIdentifierURI": "https://researchmap.jp/read0136808"}, {"nameIdentifier": "0000-0001-5005-6377", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0001-5005-6377"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2022-08-04"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "nishikawa_85_202112.pdf", "filesize": [{"value": "2.1 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 2100000.0, "url": {"label": "Full text", "url": "https://obihiro.repo.nii.ac.jp/record/4778/files/nishikawa_85_202112.pdf"}, "version_id": "0a87cd30-7b39-4982-b8eb-00265db1495b"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Malaria", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Toxoplasmosis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Plasmodium falciparum", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Toxoplasma gondii", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Mongolian compound library", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Evaluation of Mongolian compound library for potential antimalarial and anti-Toxoplasma agents", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Evaluation of Mongolian compound library for potential antimalarial and anti-Toxoplasma agents", "subitem_title_language": "en"}]}, "item_type_id": "2", "owner": "12", "path": ["5"], "permalink_uri": "https://obihiro.repo.nii.ac.jp/records/4778", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2022-08-04"}, "publish_date": "2022-08-04", "publish_status": "0", "recid": "4778", "relation": {}, "relation_version_is_last": true, "title": ["Evaluation of Mongolian compound library for potential antimalarial and anti-Toxoplasma agents"], "weko_shared_id": -1}
Evaluation of Mongolian compound library for potential antimalarial and anti-Toxoplasma agents
https://obihiro.repo.nii.ac.jp/records/4778
https://obihiro.repo.nii.ac.jp/records/4778ad9f5d33-7448-49c1-a649-c6dbd38ed973
名前 / ファイル | ライセンス | アクション |
---|---|---|
Full text (2.1 MB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
公開日 | 2022-08-04 | |||||||||
タイトル | ||||||||||
言語 | en | |||||||||
タイトル | Evaluation of Mongolian compound library for potential antimalarial and anti-Toxoplasma agents | |||||||||
言語 | ||||||||||
言語 | eng | |||||||||
キーワード | ||||||||||
主題Scheme | Other | |||||||||
主題 | Malaria | |||||||||
キーワード | ||||||||||
主題Scheme | Other | |||||||||
主題 | Toxoplasmosis | |||||||||
キーワード | ||||||||||
主題Scheme | Other | |||||||||
主題 | Plasmodium falciparum | |||||||||
キーワード | ||||||||||
主題Scheme | Other | |||||||||
主題 | Toxoplasma gondii | |||||||||
キーワード | ||||||||||
主題Scheme | Other | |||||||||
主題 | Mongolian compound library | |||||||||
資源タイプ | ||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
資源タイプ | journal article | |||||||||
著者 |
Banzragchgarav, Orkhon
× Banzragchgarav, Orkhon× Ariefta, Nanang R.× Murata, Toshihiro× Myagmarsuren, Punsantsogvoo× Battsetseg, Badgar× Battur, Banzragch× Batkhuu, Javzan× 西川, 義文
WEKO
176
|
|||||||||
抄録 | ||||||||||
内容記述タイプ | Abstract | |||||||||
内容記述 | 179 compounds in a Mongolian compound library were investigated for their inhibitory effect on the in vitro growth of Plasmodium falciparum and Toxoplasma gondii. Among these compounds, brachangobinan A at a half-maximal inhibition concentration (IC50) of 2.62 μM and a selectivity index (SI) of 27.91; 2-(2′-hydroxy-5′-O-methylphenyl)-5-(2″,5″-dihydroxyphenyl)oxazole (IC50 3.58 μM and SI 24.66); chrysosplenetin (IC50 3.78 μM and SI 15.26); 4,11-di-O-galloylbergenin (IC50 3.87 μM and SI 13.38); and 2-(2′,5′-dihydroxyphenyl)-5-(2″-hydroxyphenyl)oxazole (IC50 6.94 μM and SI 11.48) were identified as potential inhibitors of P. falciparum multiplication. Additionally, tricin (IC50 12.94 μM and SI > 23.40) was identified as a potential inhibitor of T. gondii multiplication. Our findings represent a good starting point for developing novel antimalarial and anti-Toxoplasma therapeutics from Mongolian compounds. | |||||||||
言語 | en | |||||||||
書誌情報 |
en : Parasitology International 巻 85, p. 102424, 発行日 2021-12 |
|||||||||
出版者 | ||||||||||
出版者 | Elsevier | |||||||||
ISSN | ||||||||||
収録物識別子タイプ | ISSN | |||||||||
収録物識別子 | 13835769 | |||||||||
書誌レコードID | ||||||||||
収録物識別子タイプ | NCID | |||||||||
収録物識別子 | AA11112001 | |||||||||
DOI | ||||||||||
関連タイプ | isVersionOf | |||||||||
識別子タイプ | DOI | |||||||||
関連識別子 | info:doi/10.1016/j.parint.2021.102424 | |||||||||
フォーマット | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | application/pdf | |||||||||
著者版フラグ | ||||||||||
出版タイプ | AM | |||||||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
日本十進分類法 | ||||||||||
主題Scheme | NDC | |||||||||
主題 | 649 |