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Olive-Derived Hydroxytyrosol Shows Anti-inflammatory Effect without Gastric Damage in Rats
https://obihiro.repo.nii.ac.jp/records/4391
https://obihiro.repo.nii.ac.jp/records/4391bbddc7d6-f830-4b3a-9156-e9b8e53942ca
名前 / ファイル | ライセンス | アクション |
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fulltext (5.0 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||||
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公開日 | 2019-08-08 | |||||||
タイトル | ||||||||
言語 | en | |||||||
タイトル | Olive-Derived Hydroxytyrosol Shows Anti-inflammatory Effect without Gastric Damage in Rats | |||||||
言語 | ||||||||
言語 | eng | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | Anti-inflammatory | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | Aspirin | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | Carrageenan | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | Celecoxib | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | Hydroxytyrosol | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | Indomethacin | |||||||
資源タイプ | ||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
資源タイプ | journal article | |||||||
著者 |
Yonezawa, Yutaka
× Yonezawa, Yutaka× Kihara, Tohru× Ibi, Kanata× Senshu, Masanori× Nejishima, Hiroaki× 武田, 洋平× Imai, Kunitoshi
WEKO
328
× 小川, 晴子 |
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抄録 | ||||||||
内容記述タイプ | Abstract | |||||||
内容記述 | Hydroxytyrosol (HT) is a simple phenol compound present in olive oil. In a previous in vitro study, we showed that HT downregulated lipopolysaccharide-mediated expression of inducible nitric oxide synthase, cyclooxygenase-2 (COX-2), tumor necrosis factor alpha, and interleukin-1β, resulting in reduced nitric oxide and prostaglandin E2 production. In the present study, we aimed to determine whether HT suppresses COX-2-induced inflammation in a carrageenan-induced rat paw edema model. Additionally, we compared its activity with those of the selective COX-2 inhibitor, celecoxib for a comparative control, and a representative nonsteroidal anti-inflammatory drug (NSAID), indomethacin for a positive control. HT, celecoxib, and indomethacin significantly suppressed swelling in carrageenan-injected rat paws. Although HT was less effective than celecoxib and indomethacin, it had a delayed onset of action. Moreover, we evaluated whether HT aggravates gastric damage, which is a typical adverse effect associated with NSAIDs and COX-2 inhibitors under low dose aspirin (LDA) treatment, in an aspirin-induced gastric damage rat model. Unlike celecoxib and indomethacin, HT did not cause gastric damage when co-administered with aspirin. Our results indicate that HT exerts a delayed but sustained anti-inflammatory effect against COX-2-mediated inflammation. Finally, the combination of short-acting conventional anti-inflammatory drugs and long-acting HT can be considered a new, safe, and effective anti-inflammatory treatment modality even when continuously administered for a long period under LDA treatment. © 2019 The Pharmaceutical Society of Japan. | |||||||
言語 | en | |||||||
書誌情報 |
en : Biological and Pharmaceutical Bulletin 巻 42, 号 7, p. 1120-1127, 発行日 2019-05 |
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出版者 | ||||||||
言語 | en | |||||||
出版者 | Pharmaceutical Society of Japan | |||||||
ISSN | ||||||||
収録物識別子タイプ | PISSN | |||||||
収録物識別子 | 09186158 | |||||||
書誌レコードID | ||||||||
収録物識別子タイプ | NCID | |||||||
収録物識別子 | AA10885497 | |||||||
DOI | ||||||||
関連タイプ | isIdenticalTo | |||||||
識別子タイプ | DOI | |||||||
関連識別子 | info:doi/10.1248/bpb.b18-00979 | |||||||
フォーマット | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | application/pdf | |||||||
著者版フラグ | ||||||||
出版タイプ | VoR | |||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
日本十進分類法 | ||||||||
主題Scheme | NDC | |||||||
主題 | 649 |