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Probucol induces the generation of lipid peroxidation products in erythrocytes and plasma of male cynomolgus macaques
https://obihiro.repo.nii.ac.jp/records/4376
https://obihiro.repo.nii.ac.jp/records/437697383a3e-5956-499a-943d-3b1c3dae2de9
名前 / ファイル | ライセンス | アクション |
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fulltext (1.4 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-06-13 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Probucol induces the generation of lipid peroxidation products in erythrocytes and plasma of male cynomolgus macaques | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Antimalarial drug | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Cynomolgus macaque | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Oxidative stress | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Probucol | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | αtocopherol | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Shichiri, Mototada
× Shichiri, Mototada× Ishida, Noriko× Hagihara, Yoshihisa× Yoshida, Yasukazu× Kume, Aiko× Suzuki, Hiroshi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We previously reported that probucol, a lipid lowering agent, protected mice from malaria infection via depletion in plasma α tocopherol. The antioxidant αtocopherol in host circulation is necessary for the malaria parasites to protect themselves from oxidative stress in erythrocytes where high amounts of reactive oxygen species are generated. To assess the potential for the clinical application of probucol as an antimalarial therapy, it was necessary to determine the effects of probucol by using primate experiments. Here we verified that probucol induces an α tocopherol decrement in cynomolgus macaque erythrocytes and plasma. After 2 weeks of probucol administration at doses of 200 or 400 mg/kg/day, the αtocopherol contents in erythrocytes tended to decrease. The contents of hydroxyoctadecadienoic acids and 7βhydroxycholesterol, peroxidation products derived from linoleic acid and cholesterol, respectively, increased in erythrocytes. On the other hand, plasma αtocopherol concentration showed a marginal decrement. Plasma lipid peroxidation products were transiently increased in the early stages of probucol administration. No adverse effects were observed throughout the experiment, although the dosage of probucol was higher than the clinical maximum dosage. Considering that malaria proliferates in erythrocytes, probucolinduced disruption of redox homeostasis in erythrocytes could be effective in the inhibition of parasite proliferation. © 2019 JCBN. | |||||
言語 | en | |||||
書誌情報 |
en : Journal of Clinical Biochemistry and Nutrition 巻 64, 号 2, p. 129-142, 発行日 2019-03 |
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出版者 | ||||||
言語 | en | |||||
出版者 | The Society for Free Radical Research Japan | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 009120009 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10710201 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.3164/jcbn.18-7 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
日本十進分類法 | ||||||
主題Scheme | NDC | |||||
主題 | 649 |