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Past achievements, current situation and future challenges for vaccine development against Cryptosporidium parvum and C. hominis infections
https://obihiro.repo.nii.ac.jp/records/4318
https://obihiro.repo.nii.ac.jp/records/431899a5781f-4f54-475c-8e4a-6ab029f5826f
名前 / ファイル | ライセンス | アクション |
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full text (990.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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公開日 | 2019-02-27 | |||||||||
タイトル | ||||||||||
言語 | en | |||||||||
タイトル | Past achievements, current situation and future challenges for vaccine development against Cryptosporidium parvum and C. hominis infections | |||||||||
言語 | ||||||||||
言語 | eng | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | Cryptosporidium | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | Vaccine | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | Cryptosporidium parvum | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | Cryptosporidium hominis | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | Immunization | |||||||||
資源タイプ | ||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
資源タイプ | journal article | |||||||||
著者 |
Fereig, Ragab M.
× Fereig, Ragab M.× Abdelbaky, Hanan H.× 西川, 義文
WEKO
176
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抄録 | ||||||||||
内容記述タイプ | Abstract | |||||||||
内容記述 | In developing and developed countries, infection with Cryptosporidium species is considered as a disease of major health and economic concerns. Among the several identified species, C. parvum (zoonotic and anthroponotic agent) and C. hominis (anthroponotic agent) are the most important species, inducing diarrhea in humans and calves. Fatality of cryptosporidiosis in AIDS patients and immunocompromized individuals engender the importance of immune response against such disease. As most of parasitic diseases, the vaccine development against Cryptosporidium is still problematic because of great complexity of developmental parasitic stages. However, the immuno-prophylactic and therapeutic approaches have exhibited promising results in mouse and cattle models. Both cellular and humoral immunities are required for conferring protective immunity in the tested animal models. Recombinant DNA and protein based on glycoprotein Cp15 and P23 are the predominantly evaluated candidates and the mostly successful vaccine antigens. This review highlighted the previous studies with successful vaccine antigens, summarizes the current challenges and limitations, and suggests solutions for future application in vaccine development against Cryptosporidium infection. |
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言語 | en | |||||||||
書誌情報 |
en : The Journal of protozoology research 巻 28, 号 1-2, p. 39-52, 発行日 2018 |
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出版者 | ||||||||||
言語 | en | |||||||||
出版者 | National Research Center for Protozoan Diseases | |||||||||
ISSN | ||||||||||
収録物識別子タイプ | PISSN | |||||||||
収録物識別子 | 09174427 | |||||||||
書誌レコードID | ||||||||||
収録物識別子タイプ | NCID | |||||||||
収録物識別子 | AA10824856 | |||||||||
権利 | ||||||||||
言語 | en | |||||||||
権利情報 | National Research Center for Protozoan Diseases | |||||||||
フォーマット | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | application/pdf | |||||||||
著者版フラグ | ||||||||||
出版タイプ | VoR | |||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
日本十進分類法 | ||||||||||
主題Scheme | NDC | |||||||||
主題 | 649 |