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Roles of CD122+ cells in resistance against Neospora caninum infection in a murine model
https://obihiro.repo.nii.ac.jp/records/4254
https://obihiro.repo.nii.ac.jp/records/425413ca64fe-905d-4866-9500-137e9069ed87
名前 / ファイル | ライセンス | アクション |
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full text (730.5 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||
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公開日 | 2018-08-28 | |||||||||||||
タイトル | ||||||||||||||
言語 | en | |||||||||||||
タイトル | Roles of CD122+ cells in resistance against Neospora caninum infection in a murine model | |||||||||||||
言語 | ||||||||||||||
言語 | eng | |||||||||||||
キーワード | ||||||||||||||
言語 | en | |||||||||||||
主題Scheme | Other | |||||||||||||
主題 | Immune system | |||||||||||||
キーワード | ||||||||||||||
言語 | en | |||||||||||||
主題Scheme | Other | |||||||||||||
主題 | Neospora caninum | |||||||||||||
キーワード | ||||||||||||||
言語 | en | |||||||||||||
主題Scheme | Other | |||||||||||||
主題 | Parasite | |||||||||||||
資源タイプ | ||||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
資源タイプ | journal article | |||||||||||||
著者 |
西川, 義文
× 西川, 義文
WEKO
176
× Zhang, Houshuang× Ibrahim, Hany M.× Yamada, Kyoko× Nagasawa, Hideyuki× 玄, 学南
WEKO
295
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抄録 | ||||||||||||||
内容記述タイプ | Abstract | |||||||||||||
内容記述 | Innate cells, such as natural killer (NK) cells and NKT cells, play essential roles as primary effector cells at the interface between the host and parasite until establishment of adaptive immunity. However, the roles of NK and NKT cells in defense against Neospora caninum have not been well clarified. NK and NKT cells were depleted by the treatment with an anti-CD122 (interleukin-2 receptor beta chain) monoclonal antibody (mAb, TM-β1) in vivo. The parasite burden in the brain of mice was promoted by the treatment with anti-CD122 mAb. However, there was no significant difference in the infection rates between controls and the mice treated with anti-asialoGM1 antibody to deplete NK cells. Activation of CD4+ T cells was suppressed in the mice treated with anti-CD122 mAb compared with controls and the mice treated with anti-asialoGM1 antibody. On the other hand, depletion of CD122+ cells or NK cells did not affect the number of activated CD8+ T cells, dendritic cells and B cells following N. caninum infection. These results indicate that CD122+ cells (probably NKT cells) play a crucial role in host defense by activating CD4+ T cells against N. caninum infection. | |||||||||||||
言語 | en | |||||||||||||
書誌情報 |
en : Journal of Veterinary Medical Science 巻 72, 号 10, p. 1275-1282, 発行日 2010 |
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出版者 | ||||||||||||||
言語 | en | |||||||||||||
出版者 | Japanese Society of Veterinary Science | |||||||||||||
ISSN | ||||||||||||||
収録物識別子タイプ | PISSN | |||||||||||||
収録物識別子 | 09167250 | |||||||||||||
書誌レコードID | ||||||||||||||
収録物識別子タイプ | NCID | |||||||||||||
収録物識別子 | AA10796138 | |||||||||||||
DOI | ||||||||||||||
関連タイプ | isIdenticalTo | |||||||||||||
識別子タイプ | DOI | |||||||||||||
関連識別子 | info:doi/10.1292/jvms.10-0068 | |||||||||||||
フォーマット | ||||||||||||||
内容記述タイプ | Other | |||||||||||||
内容記述 | application/pdf | |||||||||||||
著者版フラグ | ||||||||||||||
出版タイプ | VoR | |||||||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||
日本十進分類法 | ||||||||||||||
主題Scheme | NDC | |||||||||||||
主題 | 649 |