WEKO3
アイテム
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Restorative Effects of A Newly Synthesized Peptide, Obiopeptide-1, in Cyclophosphamide- or Carrageenan-pretreated Mice Infected with Opportunistic Bacteria
https://obihiro.repo.nii.ac.jp/records/1719
https://obihiro.repo.nii.ac.jp/records/17190f686f07-bff6-43b5-9824-e912bfd5669f
名前 / ファイル | ライセンス | アクション |
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Prot.Vol.2-2-4.pdf (576.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||
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公開日 | 2006-12-21 | |||||||||||
タイトル | ||||||||||||
言語 | en | |||||||||||
タイトル | Restorative Effects of A Newly Synthesized Peptide, Obiopeptide-1, in Cyclophosphamide- or Carrageenan-pretreated Mice Infected with Opportunistic Bacteria | |||||||||||
言語 | ||||||||||||
言語 | eng | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | immunoregulator | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | synthesized peptide | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | immunosuppression | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | Cyclophosphamide | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | carrageenan | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | ooiopeptide | |||||||||||
資源タイプ | ||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
資源タイプ | journal article | |||||||||||
著者 |
Fujii, Yasuhiro
× Fujii, Yasuhiro× Maki, Yoshiyuki× Ito, Masanari× Saito, Atsushi
WEKO
210
× 五十嵐, 郁男
WEKO
58
× Ono, Kenichiro× Itoh, Kikuji× Suzuki, Naoyoshi |
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抄録 | ||||||||||||
内容記述タイプ | Abstract | |||||||||||
内容記述 | Large numbers of cyclophosphamide- or carrageenan-pretreated immunosuppressed adult ddY mice died within 10 days after inoculation with several species of opportunistic bacteria, including P. aeruginosa, K. pneumoniae, E. coli, S. aureus and methicillin resistant S. aureus. When immunosuppressed mice were administered bacteria in combination with two 100 μg/mouse intramuscular doses of a newly synthesized peptide, Obiopeptide-1 (OP-1), survival rates increased significantly. At 24 and 48 hours after intraperitoneal inoculation with P. aeruginosa, counts of viable organisms from the livers, spleens, lungs, hearts, and kidneys of mice that were administered cyclophosphamide in combination with OP-1 were significantly lower than counts from mice that were administered cyclophosphamide alone. Bacteriocidal activity of peritoneal cells, neutrophils and monocyte-macrophages was higher in OP-1 pretreated mice than in non-OP-1 treated mice. This newly synthesized peptide, OP-1, is a potential immunomodulator which increases host resistance against bacterial infection. The peptide may also function as a nonspecific blood stimulating factor. | |||||||||||
言語 | en | |||||||||||
書誌情報 |
en : The journal of protozoology research 巻 2, 号 2, p. 74-83, 発行日 1992-04 |
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出版者 | ||||||||||||
言語 | en | |||||||||||
出版者 | Research Center for Protozoan Molecular Immunology | |||||||||||
ISSN | ||||||||||||
収録物識別子タイプ | PISSN | |||||||||||
収録物識別子 | 09174427 | |||||||||||
書誌レコードID | ||||||||||||
収録物識別子タイプ | NCID | |||||||||||
収録物識別子 | AA10824856 | |||||||||||
権利 | ||||||||||||
言語 | en | |||||||||||
権利情報 | Research Center for Protozoan Molecular Immunology | |||||||||||
フォーマット | ||||||||||||
内容記述タイプ | Other | |||||||||||
内容記述 | application/pdf | |||||||||||
言語 | en | |||||||||||
著者版フラグ | ||||||||||||
出版タイプ | VoR | |||||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
日本十進分類法 | ||||||||||||
主題Scheme | NDC | |||||||||||
主題 | 649 |