WEKO3
アイテム
{"_buckets": {"deposit": "4b15f441-97b4-4ca3-8961-95ba57eb0ba0"}, "_deposit": {"created_by": 12, "id": "1216", "owners": [12], "pid": {"revision_id": 0, "type": "depid", "value": "1216"}, "status": "published"}, "_oai": {"id": "oai:obihiro.repo.nii.ac.jp:00001216", "sets": ["5"]}, "author_link": ["284", "2559", "2560", "2561", "2562", "2563"], "item_2_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2016-09", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "9", "bibliographicPageEnd": "650", "bibliographicPageStart": "648", "bibliographicVolumeNumber": "22", "bibliographic_titles": [{"bibliographic_title": "Journal of Infection and Chemotherapy", "bibliographic_titleLang": "en"}]}]}, "item_2_description_19": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_2_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Azole antifungals are used not only clinically for fungal infections but also used as agricultural fungicides. Recently, azole-resistant Aspergillus fumigatus containing a tandem repeat in the promoter region of cyp51A combined with amino acid substitution(s) appears in the environment in Eurasia, especially in several European countries. Although azole fungicides have been used in Japan, especially in Hokkaido, surveillance and characterization of A. fumigatus in Hokkaido have not been reported. In this study, we collected soil samples from farms that used an azole fungicide in the Tokachi area of eastern Hokkaido, isolated 91 A. fumigatus strains, and determined the minimal inhibitory concentrations of medical azoles required for these strains. Moreover, because causative agent A. fumigatus is ubiquitous in the air and acquired from the environment, we collected 22 clinical isolates of A. fumigatus to measure their susceptibility to medical azoles in a hospital in the Tokachi area. Our data show that almost all A. fumigatus isolates retained susceptibility to medical azoles. Clinical isolates OKH34 and OKH6 showed 8 and 2 mu g/mL of voriconazole, respectively, as the minimal inhibitory concentration. Both isolates did not contain tandem repeat in cyp51A promoter region. An isolate contained G448S mutation in cyp51A conferring voriconazole resistance, which is the first report from Japan. Our data shows the existence of azole-resistant and low azole-susceptible clinical isolates and highlight the necessity for continuous surveillance in Japan because resistant A. fumigatus strains can arise through clinical or environmental selection or could be introduced from overseas.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_2_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Elsevier", "subitem_publisher_language": "en"}]}, "item_2_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "info:doi/10.1016/j.jiac.2016.03.002", "subitem_relation_type_select": "DOI"}}]}, "item_2_rights_15": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "This accepted manuscript is licensed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. \u003chttp://creativecommons.org/lisenses/by-nc-nd/4.0/\u003e", "subitem_rights_language": "en"}]}, "item_2_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA11057978", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1341321X", "subitem_source_identifier_type": "PISSN"}]}, "item_2_subject_21": {"attribute_name": "日本十進分類法", "attribute_value_mlt": [{"subitem_subject": "498", "subitem_subject_scheme": "NDC"}]}, "item_2_text_25": {"attribute_name": "文献提供者", "attribute_value_mlt": [{"subitem_text_value": "豊留孝仁(tome@obihiro.ac.jp)"}]}, "item_2_textarea_24": {"attribute_name": "作業記録", "attribute_value_mlt": [{"subitem_textarea_value": "Submitted by リポジトリ管理者 repo (repo@obihiro.ac.jp) on 2017-09-01T05:00:00Z\nNo. of bitstreams: 1\nrepository.pdf: 2734212 bytes, checksum: 90da4ad83ddb8e188e2afbf9fae0ac81 (MD5)"}, {"subitem_textarea_value": "Made available in DSpace on 2017-09-01T05:00:00Z (GMT). No. of bitstreams: 1\nrepository.pdf: 2734212 bytes, checksum: 90da4ad83ddb8e188e2afbf9fae0ac81 (MD5)\n Previous issue date: 2016-09"}]}, "item_2_version_type_20": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorAffiliations": [{"affiliationNameIdentifiers": [{"affiliationNameIdentifierScheme": "ISNI", "affiliationNameIdentifierURI": "http://www.isni.org/isni/"}], "affiliationNames": [{"affiliationNameLang": "ja"}]}], "creatorNames": [{"creatorName": "Toyotome, Takahito", "creatorNameLang": "en"}, {"creatorName": "豊留, 孝仁", "creatorNameLang": "ja"}], "familyNames": [{"familyName": "Toyotome", "familyNameLang": "en"}, {"familyName": "豊留", "familyNameLang": "ja"}], "givenNames": [{"givenName": "Takahito", "givenNameLang": "en"}, {"givenName": "孝仁", "givenNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "284", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "9000017340732", "nameIdentifierScheme": "CiNii ID", "nameIdentifierURI": "http://ci.nii.ac.jp/nrid/9000017340732"}, {"nameIdentifier": "90422245", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=90422245"}, {"nameIdentifier": "read0118846", "nameIdentifierScheme": "researchmap", "nameIdentifierURI": "https://researchmap.jp/read0118846"}]}, {"creatorNames": [{"creatorName": "Fujiwara, Takayuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "2559", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kida, Hideyuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "2560", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsumoto, Munehiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "2561", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Wada, Terumi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "2562", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Komatsu, Ryoichi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "2563", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-01-30"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "JournalofInfectionandChemotherapy22(9)648-650.pdf", "filesize": [{"value": "2.7 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 2700000.0, "url": {"label": "JournalofInfectionandChemotherapy22(9)648-650.pdf", "url": "https://obihiro.repo.nii.ac.jp/record/1216/files/JournalofInfectionandChemotherapy22(9)648-650.pdf"}, "version_id": "02149cbf-07c3-46da-a6c2-5a159d202484"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Azole", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Aspergillus fumigatus", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "cyp51A", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Azole susceptibility in clinical and environmental isolates of Aspergillus fumigatus from eastern Hokkaido, Japan", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Azole susceptibility in clinical and environmental isolates of Aspergillus fumigatus from eastern Hokkaido, Japan", "subitem_title_language": "en"}]}, "item_type_id": "2", "owner": "12", "path": ["5"], "permalink_uri": "https://obihiro.repo.nii.ac.jp/records/1216", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2017-09-01"}, "publish_date": "2017-09-01", "publish_status": "0", "recid": "1216", "relation": {}, "relation_version_is_last": true, "title": ["Azole susceptibility in clinical and environmental isolates of Aspergillus fumigatus from eastern Hokkaido, Japan"], "weko_shared_id": -1}
Azole susceptibility in clinical and environmental isolates of Aspergillus fumigatus from eastern Hokkaido, Japan
https://obihiro.repo.nii.ac.jp/records/1216
https://obihiro.repo.nii.ac.jp/records/12166fa1ce6b-ffd8-4d6b-ad5f-d5673beedf3e
名前 / ファイル | ライセンス | アクション |
---|---|---|
JournalofInfectionandChemotherapy22(9)648-650.pdf (2.7 MB)
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
公開日 | 2017-09-01 | |||||||||
タイトル | ||||||||||
言語 | en | |||||||||
タイトル | Azole susceptibility in clinical and environmental isolates of Aspergillus fumigatus from eastern Hokkaido, Japan | |||||||||
言語 | ||||||||||
言語 | eng | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | Azole | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | Aspergillus fumigatus | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | cyp51A | |||||||||
資源タイプ | ||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
資源タイプ | journal article | |||||||||
著者 |
豊留, 孝仁
× 豊留, 孝仁
WEKO
284
× Fujiwara, Takayuki× Kida, Hideyuki× Matsumoto, Munehiro× Wada, Terumi× Komatsu, Ryoichi |
|||||||||
抄録 | ||||||||||
内容記述タイプ | Abstract | |||||||||
内容記述 | Azole antifungals are used not only clinically for fungal infections but also used as agricultural fungicides. Recently, azole-resistant Aspergillus fumigatus containing a tandem repeat in the promoter region of cyp51A combined with amino acid substitution(s) appears in the environment in Eurasia, especially in several European countries. Although azole fungicides have been used in Japan, especially in Hokkaido, surveillance and characterization of A. fumigatus in Hokkaido have not been reported. In this study, we collected soil samples from farms that used an azole fungicide in the Tokachi area of eastern Hokkaido, isolated 91 A. fumigatus strains, and determined the minimal inhibitory concentrations of medical azoles required for these strains. Moreover, because causative agent A. fumigatus is ubiquitous in the air and acquired from the environment, we collected 22 clinical isolates of A. fumigatus to measure their susceptibility to medical azoles in a hospital in the Tokachi area. Our data show that almost all A. fumigatus isolates retained susceptibility to medical azoles. Clinical isolates OKH34 and OKH6 showed 8 and 2 mu g/mL of voriconazole, respectively, as the minimal inhibitory concentration. Both isolates did not contain tandem repeat in cyp51A promoter region. An isolate contained G448S mutation in cyp51A conferring voriconazole resistance, which is the first report from Japan. Our data shows the existence of azole-resistant and low azole-susceptible clinical isolates and highlight the necessity for continuous surveillance in Japan because resistant A. fumigatus strains can arise through clinical or environmental selection or could be introduced from overseas. | |||||||||
言語 | en | |||||||||
書誌情報 |
en : Journal of Infection and Chemotherapy 巻 22, 号 9, p. 648-650, 発行日 2016-09 |
|||||||||
出版者 | ||||||||||
言語 | en | |||||||||
出版者 | Elsevier | |||||||||
ISSN | ||||||||||
収録物識別子タイプ | PISSN | |||||||||
収録物識別子 | 1341321X | |||||||||
書誌レコードID | ||||||||||
収録物識別子タイプ | NCID | |||||||||
収録物識別子 | AA11057978 | |||||||||
DOI | ||||||||||
関連タイプ | isVersionOf | |||||||||
識別子タイプ | DOI | |||||||||
関連識別子 | info:doi/10.1016/j.jiac.2016.03.002 | |||||||||
権利 | ||||||||||
言語 | en | |||||||||
権利情報 | This accepted manuscript is licensed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. <http://creativecommons.org/lisenses/by-nc-nd/4.0/> | |||||||||
フォーマット | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | application/pdf | |||||||||
著者版フラグ | ||||||||||
出版タイプ | AM | |||||||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
日本十進分類法 | ||||||||||
主題Scheme | NDC | |||||||||
主題 | 498 |